High serum level of soluble CD30 in acute primary HIV-1 infection

Acute primary HIV infection.

Third-generation enzyme immunoassays start to de tect anti-HIV antibodies within 20–22 days after exposure; fourthgeneration enzyme immunoassays, which test for p24 antigen and anti-HIV antibodies, can yield positive re sults within 16–18 days. RNA nucleic acid amplification testing starts to de tect HIV infection within 7–14 days. At $75 per test, these RNA tests are too costly for routine use...

High Soluble CD14 Levels at Primary HIV-1 Infection Predict More Rapid Disease Progression.

The soluble CD14 (sCD14) level was found associated with mortality during the chronic phase of human immunodeficiency virus (HIV) infection. Here we assessed its prognostic value in 138 patients with primary HIV infection. Higher sCD14 levels were associated with death, from myocardial infarction, but this was based on 3 deaths only. Among 68 untreated patients, those with higher sCD14 levels h...

Soluble CD30 and Acute Renal Allograft Rejection

Acute HIV-1 Infection.

From the Institute of Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill (M.S.C.), and the Duke Human Vaccine Institute, Duke University School of Medicine, Durham (B.F.H.) — both in North Carolina; the University of Alabama at Birmingham, Birmingham (G.M.S.); and the Weatherall Institute of Molecular Medicine and the National Institute for Health Re...

Soluble CD30 serum level--an adequate marker for allograft rejection of solid organs?

The CD30 molecule, a 120 kDa cell surface glycoprotein, is a member of the tumor necrosis factor receptor (TNF-R) superfamily and was originally identified on the surface of Reed-Sternberg cells and anaplastic large cell lymphomas in Hodgkin's disease patients. In addition to lymphoproliferative disorders the expression of CD30 was found in both activated CD8+ and CD4+ Th2 cells which lead to t...